Transforming Human
Health & Aging
Using worms.

We develop novel therapeutics derived from symbiotic organisms that modulate inflammation, metabolism, and tissue regeneration- core pathways that underlie chronic disease, resilience, and aging.

Read moreabout our work
 

Overview

Our mission is to restore missing components of the human molecular legacy.

Our mission is to restore what has been lost. The removal of intestinal worm- longtime partners in our evolution- has disrupted our gut biome and contributed to modern immune-related diseases.

We aim to return their beneficial components, without reintroducing live worms, to bring relief to millions. The name Holoclara comes from the Greek holokleros, meaning "complete."

Discover Engine

We develop drugs from organisms that rely on tuning multiple networks simultaneously.

This is the longest running drug development program in human history.

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Leadership & Governance

 

Leadership & Governance

ANDREA CHOE

ANDREA CHOE

CEO / CO-FOUNDER

ANDREA CHOE

CEO / CO-FOUNDER

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Andrea is the CEO and co-Founder of Holoclara. She received her MD at USC Keck School of Medicine and her PhD at Caltech. Her doctoral work on the evolution of symbiont chemistry laid the foundation for the technology at Holoclara.
ANDREA CHOE
BRIAN VARNUM

BRIAN VARNUM

HEAD OF RESEARCH & DEVELOPMENT

BRIAN VARNUM

HEAD OF RESEARCH & DEVELOPMENT

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Brian brings over 30 years of experience in the biotechnology industry and has served as the CEO and Chief Development Officer of Armata Pharmaceuticals, Chief Development Officer of C3 Jian, Chief Scientific Officer of Tarrot, and Executive Director of Inflammation at Amgen.
BRIAN VARNUM
HUNG NGUYEN

HUNG NGUYEN

VP PRECLINICAL DEVELOPMENT

HUNG NGUYEN

VP PRECLINICAL DEVELOPMENT

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Hung is the VP of Preclinical Development at Holoclara. He brings more than 28 years of drug development expertise from research to clinic, including 18 years at Amgen. He received his PhD from the University of Pennsylvania.

HUNG NGUYEN
OLIVER LOSÓN

OLIVER LOSÓN

VP BUSINESS OPERATIONS

OLIVER LOSÓN

VP BUSINESS OPERATIONS

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Oliver brings a diverse range of leadership skills to Holoclara, having previously overseen IP, licensing, and entrepreneurship at Caltech’s Office of Technology Transfer. He also managed R&D and business operations at 1200 Pharma, where he was part of the founding team.

OLIVER LOSÓN
MARIANA UCHOA

MARIANA UCHOA

DIRECTOR OF IMMUNOLOGY

MARIANA UCHOA

DIRECTOR OF IMMUNOLOGY

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Mariana received her PhD at USC, where her doctoral work focused on innate immune tolerance. Mari brings her immunology leadership expertise to Holoclara, with previous experience building and leading an R&D team in autoimmune therapy.

MARIANA UCHOA
NICK EVERETTS

NICK EVERETTS

COMPUTATIONAL BIOLOGIST

NICK EVERETTS

COMPUTATIONAL BIOLOGIST

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Nick is a Scientist at Holoclara with a focus on computational biology. He completed his postdoctoral work at UC Berkeley, using single cell transcriptomics to characterize novel interactions during organogenesis and tissue regeneration. He received his PhD at UC Berkeley.

NICK EVERETTS
Alice Kwon

Alice Kwon

PRINCIPAL SCIENTIST

Alice Kwon

PRINCIPAL SCIENTIST

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Alice’s doctoral work at NYU and Caltech centered on mucosal immunology, where she studied gut immune interactions and developed innovative mouse models. With over a decade of experience in host–microbe research, Alice now brings her expertise to Holoclara, translating our science into robust preclinical models.
Alice Kwon
WINNIE TAI-FERRER

WINNIE TAI-FERRER

SR. RESEARCH ASSOCIATE

WINNIE TAI-FERRER

SR. RESEARCH ASSOCIATE

LinkedIn

Winnie is a Senior Research Associate at Holoclara, with a focus on in vivo and in vitro immunology assay development. She brings more than 20 years of experience in the life science industry. She received her BS at UCLA.

WINNIE TAI-FERRER
BIOLA FATUSIN

BIOLA FATUSIN

RESEARCH ASSOCIATE

BIOLA FATUSIN

RESEARCH ASSOCIATE

LinkedIn

Biola is a Research Associate at Holoclara. She received her Bachelors of Science from Chapman University, where her laboratory research focused on microbiology and immunology. Following her graduation, she worked at Zymo Research.

BIOLA FATUSIN
SARAH TORRES

SARAH TORRES

EXECUTIVE ASSISTANT

SARAH TORRES

EXECUTIVE ASSISTANT

LinkedIn

Sarah is the Executive Assistant to the CEO.  She has extensive experience in administration and lab management in the life science research space, which includes 17 years at Caltech and City of Hope.

SARAH TORRES

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